Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
نویسندگان
چکیده
This corrects the article DOI: 10.1038/ncomms12862.
منابع مشابه
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3ζ, which has previously been implicated in regulating GPIbα function. Here we show an important role for 14-3-3ζ in regulating arterial thrombosis. Interestingly, this thrombosis defect is not rela...
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Procoagulant platelets exhibit hallmark features of apoptotic cells, including membrane blebbing, microvesiculation, and phosphatidylserine (PS) exposure. Although platelets possess many well-known apoptotic regulators, their role in regulating the procoagulant function of platelets is unclear. To clarify this, we investigated the consequence of removing the essential mediators of apoptosis, Ba...
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Platelet phosphatidylserine (PS) exposure amplifies thrombin generation by facilitating assembly of the tenase and prothrombinase complexes. In this process, PS, which had been limited to the platelet membrane inner leaflet, is rapidly equilibrated between the inner and outer leaflets of the platelet membrane. This results in the exposure of PS to the plasma milieu. The importance of PS exposur...
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When platelets are strongly stimulated, a procoagulant platelet subpopulation is formed that is characterized by phosphatidylserine (PS) exposure and epitope modulation of integrin αIIbβ3 or a loss of binding of activation-dependent antibodies. Mitochondrial permeability transition pore (mPTP) formation, which is essential for the formation of procoagulant platelets, is impaired in the absence ...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017